The beginnings of what today is known as Trung Tâm Bảo Trợ Trẻ Em Vũng Tàu started with the heart of a few people who are passionate about caring for homeless children. In April 1999 Lê Thị Trang Đài with the assistance of Chu Thị Thư and Trang Lê Thanh Hồng rented a house to provide care, love, accommodation, food and clothing to 16 children who had been living on the streets. This house was located at 168 Bình Giã Street. All three worked purely voluntarily and funded the work themselves. The name for their small organization was called Mái Ấm Tình Thương.
By the beginning of 2002 the number of children increased to 34 including street children and abandoned babies. At this point the government started to provide some financial assistance and the name of the organization became Cơ Sở Bảo Trợ Trẻ Em Vũng Tàu. Towards the end of that year children were relocated to larger premises, located at 99 Võ Thị Sáu Street. By this stage the numbers of children and babies combined had increased to 72.
An adoption permit was granted to Cơ Sở Bảo Trơ Trẻ Em Vũng Tàu by the government in August 2002. This opened the door for abandoned babies to be adopted internationally.
Lê Thị Trang Đài stepped down from being director of Trung Tâm Bảo Trợ Trẻ Em Vũng Tàu in June 2014 and was appointed director of the Ministry of Labour, Invalids and Social Affairs. At that time Chu Thị Thư was appointed the director of Trung Tâm Bảo Trợ Trẻ Em Vũng Tàu. Trang Lê Thanh Hồng continues to work at the centre.
In July 2015 the children at Trung Tâm Bảo Trợ Trẻ Em Vũng Tàu, located at 1 Phan Bội Châu relocated to the newly built centre at 26 Ngô Quyền, Phường Thắng Nhất, Vũng Tàu.